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For example, Changpusan has demonstrated significant antidepressant effects in the CUMS model, with its impact on tryptophan metabolism confirmed through metabolomic profiling [547]

No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate

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